Reiko KISHI

Professor

1. Education

M.D., Hokkaido University, School of Medicine (1971)

Ph.D., Hokkaido University, Graduate School of Medicine (1977)

M.P.H., Harvard School of Public Health(1989)

2. Professional experience

2018 – present
Distinguished professor of Hokkaido University

2015 – 2017
Eminent professor of Center for Environmental and Health Science, Hokkaido University

2010 – 2015
Director and Professor of Center for Environmental and Health Science, Hokkaido University

2002
Japan and Malaysian JICA program: Expert Scientist for Industrial Health

1997 – 2010
Professor and Chair, Department of Public Health Sciences,
Hokkaido University School of Medicine

1993
Visiting Professor, Helsinki University Hospital, Finland

1985 – 1997
Associate Professor, Sapporo Medical University School of Medicine

1979 – 80
Adjunct Assistant Professor, The University of Miami

1977 – 79
Instructor, Sapporo Medical University School of Medicine

3. Societal Activities

  • Member of Science Council of Japan (2005-2017)
  • Chairperson: Committee on Public Health Sciences (2005-2011)
  • Chairperson: Committee on Restructuring of the System Concerning Work Employment (2009-2011)
  • Chairperson: Food Hygiene Council of Japan Committee, Ministry of Health, Labor and Welfare, Japan (2005-2015)
  • Chairperson: Academic Committee, Japan Environment and Children’s Study, Ministry of Environment, Japan (2009-present)
  • Member of Labor Council of Hokkaido Government, Japan
  • Medical Adviser in Industrial Health, Hokkaido Government, Japan

4. Activities in ISEE or other Scientific Associations

  • President of 4th ISEE & ISES joint Asian Chapter Meeting (2016, Sapporo)
  • Councilor International Society of Environmental Epidemiology (ISEE, 2014–present)
  • Elected as a fellow member of the Collegium Ramazzini, Italy (2013-present)
  • BiCCA (Birth Cohort Consortium of Asia) Co-founder (2012) with Prof. Pau-Chung Chen (Taiwan) and Prof. Eunhee Ha (Korea) & Chairperson of Executive Committee (2016-2018)
  • President of 81st Annual Meeting of Japanese Association of Industrial Health (2008)
  • President of 64th Annual Meeting of Japanese Association of Public Health(2005)
  • President of the Japanese Society of Cancer Epidemiology (2003)
  • Member, Scientific Committee of Neurotoxicity and Psychophysiology of International Commission on Occupational Health (ICOH),(1991-present)
  • Member, International Society of Environmental Epidemiology (ISEE)
  • Member, International Epidemiological Association (IEA)

5. Honors and Awards

  • The Japanese Society for Hygiene Award (2012)
    For Life Course Approaches of the Large Scale Birth Cohort Studies of Children; Environment and Children’s Health, Development , Allergy and Malformation.
  • Highest Academic Prize for the Distinguished Research of the JapanMedical Association (2009);
    For Long-Term Scientific Efforts to Elucidate the Subtle Environmental Health Risks to Workers and the Vulnerable Population, i.e., Children and Offspring, Due to Environmental Chemicals.
  • Outstanding Research Award, Japan Society for Occupational Health (2003)
    For New Methodological Developments for the Risk Assessment of Workers Exposed to Organic Solvents, Metals and Other Potential Neurobehavioral Hazards in the Workplace

6. Research Fields

  • Birth cohort studies of environment and children’s health (malformation, allergy, and development)
  • Indoor air quality and related athma/allergy including sick-building syndromes
  • Experimental studies on environmental toxicology
  • Occupational Cancer Epidemiology and Neurobehavioral Disorders Among Workers Exposed to Environmental Chemicals
  • Occupational stress and physical and mental health of workers
  • Social support networks and preventive care for the elderly
  • Others

7. Cohort profile of the Hokkaido Studies

  1. Kishi R., Araki A., Minatoya M., Itoh S., Goudarzi H., Miyashita C.; Birth cohorts in Asia: The importance, advantages, and disadvantages of different-sized cohorts. Science of the Total Environment. 615 1143-1154, 2018.
  2. Kishi R., Araki A., Minatoya M., Hanaoka T., Miyashita C., Itoh S., Kobayashi S., Ait Bamai Y., Yamazaki K., Miura R., Tamura N., Ito K., Goudarzi H.; The Hokkaido birth cohort study on environment and children’s health: Cohort profile – updated 2017. Environmental Health and Preventive Medicine. 22-46, 2017.
  3. Kishi R., Zhang J. J., Ha E. H., Chen P. C., Tian Y., Xia Y., Tsuchiya K. J., Nakai K., Kim S., Hong S. J., Hong Y. C., Lee J. R., Mohamed H. J. B. J., Parajuli R. P., Adair L. S., Chong Y. S., Guo Y. L., Wang S. L., Nishijo M., Kido T., Tai P. T., Nandasena S.; Birth Cohort Consortium of Asia (BiCCA) – Current and Future Perspectives. Epidemiology. 28 (1):S19-S34, 2017.
  4. Kishi R., Kobayashi S., Ikeno T., Araki A., Miyashita C., Itoh S., Sasaki S., Okada E., Kobayashi S., Kashino I., Itoh K., Nakajima S., Health. The members of the Hokkaido Study on Environment and Children’s; Ten Years of Progress in the Hokkaido Birth Cohort Study on Environment and Children’s Health: Cohort Profile – Updated 2013. Environ Health Prev Med. 18 (6):429-450, 2013.
  5. Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F, Saijo Y, Kurahashi N, Tamaki J, Endo T, Sengoku K, Nonomura K, Minakami H: Cohort Profile: The Hokkaido Study on Environment and Children’s Health in Japan. Int J Epidemiol. 40:611-618, 2011

8. Selected Papers from 2005-2020

  1. Kashino I, Sasaki S, Okada E, Mtsuura H, Goudarzi H,Miyashita C, Okada E, Ito Y, Araki A, Kishi R. Effects of prenatal Exposure to 11 perfluoroalkyl substances on fetal growth: a large-scale, prospective birth cohort study, Environment International. 2019 in press
  2. Itoh S., Araki A., Miyashita C., Yamazaki ⁠K., Goudarzi H., Minatoya M., Ait Bamai Y., Kobayashi S., Okada E., Kashino I., Yuasa M., Baba T., Kishi R., Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study., Environment International, 133, PartA, 105139, 2019
  3. Miura R, Araki A, Minatoya M, Miyake K, Chen ML, Kobayashi S, Miyashita C, Yamamoto J, Matsumura J, Ishizuka M, Kubota T, Kishi R, An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A, Scientific Reports, 9(1), 12369, 2019
  4. Ait Bamai Y, Bastiaensen M, Araki A, Goudarzi H, Konno S, Ito S, Miyashita C, Yao Y, Covaci A, Kishi R, Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study, Environment International, 131, 105003, 2019
  5. Kobayashi S., Sata F., Hanaoka T., Braimoh T. S., Ito K., Tamura N., Araki A., Ito S., Miyashita C., Kishi R.; Association between maternal passive smoking and incresed risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from the Hokkaido Study: a prospective birth cohort. BMJ Open. doi:10.1136/bmjopen-2018-023200. 2019.
  6. Miyashita C., Araki A., Mitsui T., Itoh S., Goudarzi H., Sasaki S., Kajiwara J., Hori H., Cho K., Moriya K., Shinohara N., Nonomura K., Kishi R.; Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: the Hokkaido Study. Environment International. 117 175-185, 2018.
  7. Miyake K., Kawaguchi A., Miura R., Kobayashi S., Tran N. Q. V., Koybayashi S., Miyashita C., Araki A., Kubota T., Yamagata Z., Kishi R.; Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children’s Health. Scientific Report. 2018. DOI:10.1038/s41598-018-23772-x
  8. Araki A., Miyashita C., Mitsui T., Goudarzi H., Mizutani F., Chisaki Y., Itoh S., Sasaki S., Cho K., Moriya K., Shinohara N., Nonomura K., Kishi R.; Prenatal organochlorine pesticide exposure and the disruption of steroids and reproductive hormones in cord blood: The Hokkaido study. Environ Int. 110 1-13, 2018.
  9. Miura R., Araki A., Miyashita C., Kobayashi Su., Kobayashi Sa., Wang SL., Chen CH., Miyake K., Ishizuka M., Iwasaki Y., YM. Ito, Kubota T., Kishi R.; An epigenome-wide study of cord blood DNA methylations in relation to prenatal perfluoroalkyl substance exposure: the Hokkaido study. Environment International. 115 21-28, 2018.
  10. Tamura N., Hanaoka T., Ito K., Araki A., Miyashita C., Ito S., Minakami H., Cho K., Endo T., Sengoku K., Ogasawara K., Kishi R.; Different Risk Factors for Very Low Birth Weight, Term-Small-for-Gestational-Age, or Preterm Birth in Japan. International Journal of Environmental Research and Public Health. 15 (369):2018.
  11. Goudarzi H., Araki A., Itoh S., Sasaki S., Miyashita C., Mitsui T., Nakazawa H., Nonomura K., Kishi R.; The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study. Environ Health Perspect. 125 (1):111-118, 2017.
  12. Kobayashi S., Sata F., Miyashita C., Sasaki S., Ban S., Araki A., Goudarzi H., Kajiwara J., Todaka T., Kishi R.; Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: The Hokkaido Study. Reprod Toxicol. 67 111-116, 2017.
  13. Kobayashi S., Sata F., Sasaki S., Braimoh T. S., Araki A., Miyashita C., Goudarzi H., Kobayashi S., Kishi R.; Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: dose-dependent association of plasma cotinine with infant birth size among Japanese women―The Hokkaido Study. Reproductive Toxicology. 94-103, 2017.
  14. Minatoya M., Araki A., Miyashita C., Sasaki S., Goto Y., Nakajima T., Kishi R.; Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size: The Hokkaido study on environment and children’s health. Sci Total Environ. 579 606-611, 2017.
  15. Goudarzi H., Miyashita C., Okada E., Kashino I., Kobayashi S., Chen C. J., Ito S., Araki A., Matsuura H., Ito Y. M., Kishi R.; Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children. Environ Int. 94 124-132, 2016.
  16. Kobayashi S., Sata F., Sasaki S., Braimoh T. S., Araki A., Miyashita C., Goudarzi H., Kobayashi S., Kishi R.; Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study. Reprod Toxicol. 65 295-306, 2016.
  17. Goudarzi H., Miyashita C., Okada E., Kashino I., Kobayashi S., Chen C. J., Ito S., Araki A., Matsuura H., Ito Y. M., Kishi R.; Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children. Environ Int. 94 124-132, 2016.
  18. Yila T. A., Araki A., Sasaki S., Miyashita C., Itoh K., Ikeno T., Yoshioka E., Kobayashi S., Goudarzi H., Baba T., Braimoh T., Minakami H., Endo T., Sengoku K., Kishi R.; Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children’s Health, 2002-2012. Br J Nutr. 115 (12):2227-35, 2016.
  19. Kishi R., Nakajima T., Goudarzi H., Kobayashi S., Sasaki S., Okada E., Miyashita C., Ito S., Araki A., Ikeno T., Iwasaki Y. and Nakazawa H.,; The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Essential and Long Chain Polyunsaturated Fatty Acids during Pregnancy and the Birth Weight of their Offspring: The Hokkaido Study, Environ Health Perspect. 124, (10):1038-45, 2015
  20. Araki A., Mitsui T., Miyashita C., Nakajima T., Naito H., Ito S., Sasaki S., Cho K., Ikeno T., Nonomura K., Kishi R.; Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido Study on Environment and Children’s Health. PLOS ONE. 9 (10):e109039, 2014.
  21. Sasaki S, Braimoh TS, Yila TA, Yoshioka E, Kishi R: Self-reported tobacco smoke exposure and plasma cotinine levels during pregnancy – A validation study in Northern Japan. Sci Total Environ. 412-413:114-118, 2011
  22. Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R: Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Environ Health Perspect. 117:660-667, 2009
  23. Konishi K, Sasaki S, Kato S, Ban S, Washino N, Kajiwara J, Todaka T, Hirakawa H, Hori T, Yasutake D, Kishi R: Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight. Environ Res. 109:906-913, 2009
  24. Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R: Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1. Am J Epidemiol. 167:719-726, 2008
  25. Kishi R, Sata F, Yoshioka E, Ban S, Sasaki S, Konishi K, Washino N: Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals on the next generation. Basic Clin Pharmacol Toxicol. 102:191-203, 2008
  26. Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A, Kanagami N, Hirakawa H, Hori T, Tobiishi K, Todaka T, Nakamura Y, Yanagiya S, Sengoku Y, Iida T, Sata F et al: Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect. 114:773-778, 2006
  27. Kurahashi N, Sata F, Kasai S, Shibata T, Moriya K, Yamada H, Kakizaki H, Minakami H, Nonomura K, Kishi R: Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias. Mol Hum Reprod. 11:93-98, 2005

9. List of Publications in English by Research Categories(total 258)

Ⅰ. Books
  1. Kishi R, Grandjean P (eds): Health Impacts of Developmental Exposure to Environmental Chemicals, e-book series Springer Nature. 2019 in press
  2. Kishi R, Norbäck D, Araki A (eds): Indoor Environmental Quality and Health Risk toward Healthier Environment for All, e-book series Springer Nature. 2019
  3. Kishi R, Araki A, Miyashita C, Kobayashi S, Miura R, Minatoya M: The Hokkaido Study on Environment and Children’s Health, Sata F, Fukuoka H, Hanson M. (eds)., Pre-emptive Medicine: Public Health Aspects of developmental Origins of Health and Diseases, e-book series Springer Nature. 2018
  4. Kishi R, Doi R, Fukuchi Y, Satoh H, Ono A, Morikawa F, Tashiro K, Takahata N: Subjective symptoms and neurobehavioral performances of ex-mercury miners at an average of 18 years after the cessation of chronic exposure to mercury vapor. Shunichi Araki ed. Neurobehavioral Methods and Effects in Occupational and Environmental Health. 141-154, 1994
  5. Kishi R, Ishizu S, Itoh I, Katoh N, Miyake H, Harabuchi I: Health research on methyl 　　bromide manufacturing workers, Part 1:Symptoms of long-term exposure. Occupational Health in the Chemical Industry (E.C. Grandjean ed.) 8120-134, 1988
  6. Ikeda T, Kishi R, Miyake H: Combined effects of toluene and diazepam on signalled conditioned avoidance performance in rats. In: Okada A, Manninen O (eds). Recent Advances in Research on the Combined Effects of Environmental Factors, Kanazawa, Japan: Kyoei. 897-916, 1987
Ⅱ. Original Papers

1. Birth cohort studies of environment and children’s health (malformation, allergy, and development) and related papers including maternal/child genetic polymorphism and the risk of pregnancy related disorders (131papers)

  1. Kashino I, Sasaki S, Okada E, Mtsuura H, Goudarzi H,Miyashita C, Okada E, Ito Y, Araki A, Kishi R. Effects of prenatal Exposure to 11 perfluoroalkyl substances on fetal growth: a large-scale, prospective birth cohort study, Environment International. 2019 in press
  2. Minatoya M, Araki A, Itoh S, Yamazaki K, Kobayashi S, Miyashita C, Sasaki S, Kishi R. Prenatal tobacco exposure and ADHD symptoms at pre-school age: the Hokkaido Study on Environment and Children’s Health, Environmental Health and Preventive Medicine. 2019 in press.
  3. Itoh S., Araki A., Miyashita C., Yamazaki ⁠K., Goudarzi H., Minatoya M., Ait Bamai Y., Kobayashi S., Okada E., Kashino I., Yuasa M., Baba T., Kishi R., Association between perfluoroalkyl substance exposure and thyroid hormone/thyroid antibody levels in maternal and cord blood: The Hokkaido Study., Environment International, 133, PartA, 105139, 2019
  4. Saijo Y., Ito Y., Yoshioka E., Sato Y., Minatoya M., Araki A., Miyashita C., Kishi R., Identifying a risk score for childhood obesity based on predictors identified in pregnant women and 1-year-old infants: An analysis of the data of the Hokkaido Study on Environment and Children’s Health, Clinical Pediatric Endocrinology, 28(3), 81-89, 2019
  5. Miura R, Araki A, Minatoya M, Miyake K, Chen ML, Kobayashi S, Miyashita C, Yamamoto J, Matsumura J, Ishizuka M, Kubota T, Kishi R, An epigenome-wide analysis of cord blood DNA methylation reveals sex-specific effect of exposure to bisphenol A, Scientific Reports, 9(1), 12369, 2019
  6. Ait Bamai Y, Bastiaensen M, Araki A, Goudarzi H, Konno S, Ito S, Miyashita C, Yao Y, Covaci A, Kishi R, Multiple exposures to organophosphate flame retardants alter urinary oxidative stress biomarkers among children: The Hokkaido Study, Environment International, 131, 105003, 2019
  7. Kawanishi Y, Yoshioka E, Saijo Y, ITOH T, Miyamoto T, Sengoku K, Ito Y, Ito S, Miyashita C, Araki A, Endo T, Cho K, Minakami H, Kishi R, for the Japan Environment and Children’s Study Group, The Relationship between Prenatal Psychological Stress and Placental Abruption in Japan, The Japan Environment and Children’s Study (JECS), PLOS One, 14(7):e0219379, 2019
  8. Kobayashi S., Sata F., Murata K., Saijo Y., Araki A., Miyashita C., Itoh S., Minatoya M., Yamazaki K., Ait Bamai Y., Kishi R., Japan Environment and Children’s Study Group. Dose-dependent associations between prenatal caffeine consumption and small-for-gestational-age, preterm birth, and reduced birthweight in the Japan Environment and Children’s Study. Paediatric and Perinatal Epidemiology, 33(3), 185-194, 2019
  9. Kobayashi S., Kishi R., Saijo Y., Ito Y., Oba K., Araki A., Miyashita C., Itoh S., Minatoya M., Yamazaki K., Ait Bamai Y., T. Sato., Yamazaki S., Nakayama S. F., Isobe T., Nitta H, Japan Environment and Children’s Study Group. Association of blood mercury levels during pregnancy with infant birth size by blood selenium levels in the Japan Environment and Children’s Study: a prospective birth cohort. Environment International. 125: 418-429, 2019
  10. Kobayashi S., Sata F., Hanaoka T., Braimoh T. S., Ito K., Tamura N., Araki A., Ito S., Miyashita C., Kishi R.; Association between maternal passive smoking and incresed risk of delivering small-for-gestational-age infants at full-term using plasma cotinine levels from the Hokkaido Study: a prospective birth cohort. BMJ Open. doi:10.1136/bmjopen-2018-023200. 2019.
  11. Nishimura Y., Moriya K., Kobayashi S., Araki A., Sata F., Mitsui T., Itoh S., Miyashita C., Cho K., Kon M, Nakamura M., Kitta T., Murai S., Kishi R., Shinohara N.; Association between ESR1 polymorphisms and second to fourth digit ratio in school-aged children in the Hokkaido Study. Steroids. 2018
  12. Mitsui T., Araki A., Miyashita C., Ito S., Ikeno T., Sasaki S., Kitta T., Moriya K., Cho K., Morioka K., Kishi R., Shinohara N., Takeda M., Nonomura K.; Effects of prenatal sex hormones on behavioral sexual dimorphism. Pediatrics International. in press
  13. Ito K., Hanaoka T., Tamura N., Sasaki S., Miyashita C., Araki A., Ito S., Minakami H., Cho K., Endo T., Baba T., Miyamoto T., Sengoku K., Tamakoshi A., Kishi R.; Association between maternal serum folate concentrations in the first trimester and the risk of birth defects: the Hokkaido Study of Environment and Children’s Health. Journal of Epidemiology. https://doi.org/10.2188/jea.JE20170185, 2018.【ADVANCE ONLINE PUBLICATION】
  14. Yamazaki K., Araki A., Nakajima S., Miyashita C., Ikeno T., Itoh S., Minatoya M., Kobayashi S., Mizutani F., Chisaki Y., Kishi R.; Association between prenatal exposure to organochlorine pesticides and the mental and psychomotor development of infants at ages 6 and 18 months: The Hokkaido Study on Environment and Children’s Health. Neurotoxicology. 69, 201-208, 2018.
  15. Itoh S., Baba T., Yuasa M., MIyashita C., Kobayashi S., Araki A., Sasaki S., Kajiwara J., Hori T., Todaka T., Fujikura K., Nakajima S., Kato S., Kishi R.; Association of Maternal Serum Concentration of Hydroxylated Polychlorinated Biphenyls with Maternal and Neonatal Thyroid Hormones: The Hokkaido Birth Cohort Study Environmental Research.167, 583-590, 2018.
  16. Araki A., Bastiaensen M., Ait Bamai Y., Van den Eede N., Kawai T., Tsuboi T., Mesfin R. K., Covaci A., Kishi R.; Associations between allergic symptoms and phosphate flame retardants in dust and their urinary metabolites among school children. Environment International. 119, 438-446, 2018.
  17. Tsai M.-S., Miyashita C., Araki A., Itoh S., Ait Bamai Y., Goudarzi H., Okada E., Kashino I., Matsuura H., Kishi R.; Determinants and temporal trends of perfluoroalkyl substances in pregnant women: The Hokkaido Study on Environment and Children’s Health. International Journal of Environmental Research and Public Health. 15 (5) 989, 2018.
  18. Goudarzi H., Konno S., Kimura H., Araki A., Miyashita C., Itoh S., Ait Bamai Y., Kimura H., Shimizu K., Suzuki M., Ito Y. M., Nishimura M., Kishi R.; Contrasting associations of maternal smoking and pre-pregnancy BMI with wheeze and eczema in children. Science of the Total Environment. 639. 1601-1609, 2018.
  19. Mitsui T., Araki A., Goudarzi H., Miyashita C., Ito S., Sasaki S., Kitta T., Moriya K., Cho K., Morioka K., Kishi R., Shinohara N., Takeda M., Nonomura K.; Relationship between adrenal steroid hormones in cord blood and birth weight: The Sapporo Cohort, Hokkaido Study on Environment and Children’s Health. American Journal of Human Biology. e23127, 2018. [Epub ahead of print]
  20. Miyashita C., Araki A., Mitsui T., Itoh S., Goudarzi H., Sasaki S., Kajiwara J., Hori H., Cho K., Moriya K., Shinohara N., Nonomura K., Kishi R.; Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: the Hokkaido Study. Environment International. 117 175-185, 2018.
  21. Miyake K., Kawaguchi A., Miura R., Kobayashi S., Tran N. Q. V., Koybayashi S., Miyashita C., Araki A., Kubota T., Yamagata Z., Kishi R.; Association between DNA methylation in cord blood and maternal smoking: The Hokkaido Study on Environment and Children’s Health. Scientific Report. 2018. DOI:10.1038/s41598-018-23772-x
  22. Ait Bamai Y., Miyashita C., Araki A., Nakajima T., Sasaki S., Kishi R.; Effects of prenatal di(2-ethylhexyl) phthalate exposure on childhood allergies and infectious diseases: the Hokkaido Study on Environment and Children’s Health. Science of the Total Environment. 618:1408-1415, 2018.
  23. Araki A., Miyashita C., Mitsui T., Goudarzi H., Mizutani F., Chisaki Y., Itoh S., Sasaki S., Cho K., Moriya K., Shinohara N., Nonomura K., Kishi R.; Prenatal organochlorine pesticide exposure and the disruption of steroids and reproductive hormones in cord blood: The Hokkaido study. Environ Int. 110 1-13, 2018.
  24. Baba T., Ito S., Yuasa M., Yoshioka E., Miyashita C., Araki A., Sasaki S., Kobayashi S., Kajiwara J., Hori T., Kato S., Kishi R.; Association of prenatal exposure to PCDD/Fs and PCBs with maternal and infant thyroid hormones: The Hokkaido Study on Environment and Children’s Health. Sci Total Environ. 615 1239-1246, 2018.
  25. Hanaoka T., Tamura N., Ito K., Sasaki S., Araki A., Ikeno T., Miyashita C., Ito S., Minakami H., Cho K., Endo T., Baba T., Miyamoto T., Sengoku K., Kishi R., and other members of the Hokkaido Study on Environment and Children’s Health; Prevalence and Risk on Birth Defects Observed in a Prospective Cohort Study; the Hokkaido Study on Environment and Children’s Health. J Epidemiol. 28(3): 125–132. 2018.
  26. Ikeno T., Miyashita C., Nakajima S., Kobayashi S., Yamazaki K., Saijo Y., Kita T., Sasaki S., Konishi K., Kajiwara J., Hori T., Kishi R.; Effects of low-level prenatal exposure to dioxins on cognitive development in Japanese children at 42 months. Science of the Total Environment, Special Issue. 618 1423-1430, 2018.
  27. Kishi R., Araki A., Minatoya M., Itoh S., Goudarzi H., Miyashita C.; Birth cohorts in Asia: The importance, advantages, and disadvantages of different-sized cohorts. Science of the Total Environment. 615 1143-1154, 2018.
  28. Minatoya M., Araki A., Miyashita C., Ait Bamai Y., Itoh S., Yamamoto J., Onoda Y., Ogasawara K., Matsumura T., Kishi R.; Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido Study on Environment and Children’s Health. Environ Res. 161 505-511, 2018.
  29. Minatoya M., Itoh S., Araki A., Tamura N., Yamazaki K., Miyashita C., Kishi R.; Association between fetal adipokines and child behavioral problems at preschool age: The Hokkaido Study on Environment and Children’s Health. Int. J. Environ. Res. Public Health. 15(1) (120):2018.
  30. Miura R., Araki A., Miyashita C., Kobayashi Su., Kobayashi Sa., Wang SL., Chen CH., Miyake K., Ishizuka M., Iwasaki Y., YM. Ito, Kubota T., Kishi R.; An epigenome-wide study of cord blood DNA methylations in relation to prenatal perfluoroalkyl substance exposure: the Hokkaido study. Environment International. 115 21-28, 2018.
  31. Tamura N., Hanaoka T., Ito K., Araki A., Miyashita C., Ito S., Minakami H., Cho K., Endo T., Sengoku K., Ogasawara K., Kishi R.; Different Risk Factors for Very Low Birth Weight, Term-Small-for-Gestational-Age, or Preterm Birth in Japan. International Journal of Environmental Research and Public Health. 15 (369):2018.
  32. Minatoya M., Itoh S., Yamazaki K., Araki A., Miyashita C., Tamura N., Yamamoto J., Onoda Y., Ogasawara K., Matsuura T., Kishi R.; Prenatal exposure to bisphenol A and phthalates and behavioral problems in children at preschool age: The Hokkaido Study on Environment and Children’s Health. Environtal Health and Preventive Medicine. 23:43 2018. https://doi.org/10.1186/s12199-018-0732-1
  33. Ait Bamai Y., Araki A., Nomura T., Kawai T., Tsuboi T., Kobayashi S., Miyashita C., Takeda M., Shimizu H., Kishi R.; Association of filaggrin gene mutations and childhood eczema and wheeze with phthalates and phosphorus flame retardants in house dust: The Hokkaido study on Environment and Childern’s Health. Environtent International. 121 102-110, 2018.
  34. Araki A., Mitsui T., Goudarzi H., Nakajima T., Miyashita C., Itoh S., Sasaki S., Cho K., Moriya K., Shinohara N., Nonomura K., Kishi R.; Prenatal di(2-ethylhexyl) phthalate exposure and disruption of adrenal androgens and glucocorticoids levels in cord blood: The Hokkaido Study. Science of the Total Environment. 581-582 297-304, 2017.
  35. Braimoh T. S., Kobayashi S., Sata F., Sasaki S., Goudarzi H., Yila T. A., Araki A., Miyashita C., Minakami H., Baba T., Sengoku K., Kishi R.; Association of prenatal passive smoking and metabolic gene polymorphisms with child growth from birth to 3 years of age in the Hokkaido Birth Cohort on Environment and Children’s Health. Sci Total Environ. 605-606 995-1002, 2017.
  36. Goudarzi H., Araki A., Itoh S., Sasaki S., Miyashita C., Mitsui T., Nakazawa H., Nonomura K., Kishi R.; The Association of Prenatal Exposure to Perfluorinated Chemicals with Glucocorticoid and Androgenic Hormones in Cord Blood Samples: The Hokkaido Study. Environ Health Perspect. 125 (1):111-118, 2017.
  37. Goudarzi H., Miyashita C., Okada E., Kashino I., Chen C. J., Ito S., Araki A., Kobayashi S., Matsuura H., Kishi R.; Prenatal exposure to perfluoroalkyl acids and prevalence of infectious diseases up to 4years of age. Environ Int. 104 132-138, 2017.
  38. Kishi R., Araki A., Minatoya M., Hanaoka T., Miyashita C., Itoh S., Kobayashi S., Ait Bamai Y., Yamazaki K., Miura R., Tamura N., Ito K., Goudarzi H.; The Hokkaido birth cohort study on environment and children’s health: Cohort profile – updated 2017. Environmental Health and Preventive Medicine. 22-46, 2017.
  39. Kishi R., Zhang J. J., Ha E. H., Chen P. C., Tian Y., Xia Y., Tsuchiya K. J., Nakai K., Kim S., Hong S. J., Hong Y. C., Lee J. R., Mohamed H. J. B. J., Parajuli R. P., Adair L. S., Chong Y. S., Guo Y. L., Wang S. L., Nishijo M., Kido T., Tai P. T., Nandasena S.; Birth Cohort Consortium of Asia (BiCCA) – Current and Future Perspectives. Epidemiology. 28 (1):S19-S34, 2017.
  40. Kobayashi S., Azumi K., Goudarzi H., Araki A., Miyashita C., Kobayashi S., Itoh S., Sasaki S., Ishizuka M., Nakazawa H., Ikeno T., Kishi R.; Effects of prenatal perfluoroalkyl acid exposure on cord blood IGF2/H19 methylation and ponderal index: the Hokkaido study. Journal of Exposure Science and Environmental Epidemiology. 27 (3):251-259, 2017.
  41. Kobayashi S., Sata F., Miyashita C., Miura R., Azumi K., Kobayashi S., Goudarzi H., Araki A., Ishizuka M., Todaka T., Kajiwara J., Hori T., Kishi R.; Gender-specific association of exposure to non-dioxin-like　polychlorinated　biphenyls　during　pregnancy　with　methylation　levels　of　H19　and　long　interspersed nuclear element-1 in cord blood in the Hokkaido study. Toxicology. 390 135-145, 2017.
  42. Kobayashi S., Sata F., Miyashita C., Sasaki S., Ban S., Araki A., Goudarzi H., Kajiwara J., Todaka T., Kishi R.; Dioxin-metabolizing genes in relation to effects of prenatal dioxin levels and reduced birth size: The Hokkaido Study. Reprod Toxicol. 67 111-116, 2017.
  43. Kobayashi S., Sata F., Sasaki S., Braimoh T. S., Araki A., Miyashita C., Goudarzi H., Kobayashi S., Kishi R.; Modification of adverse health effects of maternal active and passive smoking by genetic susceptibility: dose-dependent association of plasma cotinine with infant birth size among Japanese women―The Hokkaido Study. Reproductive Toxicology. 94-103, 2017.
  44. Minatoya M., Araki A., Miyashita C., Sasaki S., Goto Y., Nakajima T., Kishi R.; Prenatal di-2-ethylhexyl phthalate exposure and cord blood adipokine levels and birth size: The Hokkaido study on environment and children’s health. Sci Total Environ. 579 606-611, 2017.
  45. Minatoya M., Araki A., Nakajima S., Sasaki S., Miyashita C., Yamazaki K., Yamamoto J., Matsumura T., Kishi R.; Cord blood BPA level and child neurodevelopment and behavioral problems: The Hokkaido Study on Environment and Children’s Health. Sci Total Environ. 607-608 351-356, 2017.
  46. Minatoya M., Itoh S., Miyashita C., Araki A., Sasaki S., Miura R., Goudarzi H., Iwasaki Y., Kishi R.; Association of prenatal exposure to perfluoroalkyl substances with cord blood adipokines and birth size: The Hokkaido Study on environment and children’s health. Environmental Research. 156 175-182, 2017.
  47. Minatoya M., Sasaki S., Araki A., Miyashita C., Itoh S., Yamamoto J., Matsumura T., Mitsui T., Moriya K., Cho K., Morioka K., Minakam H., Shinohara N., Kishi R.; Cord blood bisphenol A levels and reproductive and thyroid hormone levels of neonates: The Hokkaido Study on Environment and Children’s Health. Epidemiology. 28 Suppl 1:S3-S9 2017.
  48. Miyashita C., Ait Bamai Y., Araki A., Itoh S., Minatoya M., Kobayashi S., Kajiwara J., Hori T., Kishi R.; Prenatal exposure to dioxin-like compounds is associated with decreased cord blood IgE and increased risk of wheezing in children aged up to 7 years: The Hokkaido Study. Science of the Total Environment. 610-611 191-199, 2017.
  49. Nakajima S., Saijo Y., Miyashita C., Ikeno T., Sasaki S., Kajiwara J., Kishi R.; Sex-specific differences in effect of prenatal exposure to dioxin-like compounds on neurodevelopment in Japanese children: Sapporo cohort study. Environmental Research. 159 222-231, 2017.
  50. Sasaki S., Limpar M., Sata F., Kobayashi S., Kishi R.; Interaction between maternal caffeine intake during pregnancy and CYP1A2 C164A polymorphism affects infant birth size in the Hokkaido study. Pediatr Res. 82 19-28, 2017.
  51. Minatoya M., Itoh S., Araki A., Tamura N., Yamazaki K., Nishihara S., Miyashita C., Kishi R.; Associated factors of behavioural problems in children at preschool age: the Hokkaido study on environment and children’s health. Child Care Health Dev. 43(3):385–392, 2017.
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  53. Kawanishi Y., Saijo Y., Yoshioka E., Nakagi Y., Yoshida T., Miyamoto T., Sengoku K., Ito Y., Miyashita C., Araki A., Kishi R.; The Association between Prenatal Yoga and the Administration of Ritodrine Hydrochloride during Pregnancy: An Adjunct Study of the Japan Environment and Children’s Study. PLoS One. 11 (6):e0158155, 2016.
  54. Kato S., Itoh S., Yuasa M., Baba T., Miyashita C., Sasaki S., Nakajima S., Uno A., Nakazawa H., Iwasaki Y., Okada E., Kishi R.; Association of perfluorinated chemical exposure in utero with maternal and infant thyroid hormone levels in the Sapporo cohort of Hokkaido Study on the Environment and Children’s Health. Environ Health Prev Med. 21, 334-344, 2016.
  55. Itoh S., Araki A., Mitsui T., Miyashita C., Goudarzi H., Sasaki S., Cho K., Nakazawa H., Iwasaki Y., Shinohara N., Nonomura K., Kishi R.; Association of perfluoroalkyl substances exposure in utero with reproductive hormone levels in cord blood in the Hokkaido Study on Environment and Children’s Health. Environ Int. 94 51-59, 2016
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  57. Goudarzi H., Miyashita C., Okada E., Kashino I., Kobayashi S., Chen C. J., Ito S., Araki A., Matsuura H., Ito Y. M., Kishi R.; Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children. Environ Int. 94 124-132, 2016.
  58. Kobayashi S., Sata F., Sasaki S., Braimoh T. S., Araki A., Miyashita C., Goudarzi H., Kobayashi S., Kishi R.; Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study. Reprod Toxicol. 65 295-306, 2016.
  59. Goudarzi H., Miyashita C., Okada E., Kashino I., Kobayashi S., Chen C. J., Ito S., Araki A., Matsuura H., Ito Y. M., Kishi R.; Effects of prenatal exposure to perfluoroalkyl acids on prevalence ofallergic diseases among 4-year-old children. Environ Int. 94 124-132, 2016.
  60. Yila T. A., Araki A., Sasaki S., Miyashita C., Itoh K., Ikeno T., Yoshioka E., Kobayashi S., Goudarzi H., Baba T., Braimoh T., Minakami H., Endo T., Sengoku K., Kishi R.; Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children’s Health, 2002-2012. Br J Nutr. 115 (12):2227-35, 2016.
  61. Yamamoto J., Minatoya M., Sasaki S., Araki A., Miyashita C., Matsumura T., Kishi R.; Quantifying bisphenol A in maternal and cord whole blood using isotope dilution liquid chromatography/tandem mass spectrometry and maternal characteristics associated with bisphenol A. Chemosphere. 164 25-31, 2016.
  62. Mitsui T., Araki A., Miyashita C., Ito S., Ikeno T., Sasaki S., Kitta T., Moriya K., Cho K., Morioka K., Kishi R., Shinohara N., Takeda M., Nonomura K.; The Relationship between the Second-to-Fourth Digit Ratio and Behavioral Sexual Dimorphism in School-Aged Children. PLoS One. 11 (1):e0146849, 2016.
  63. Mitsui T., Araki A., Goudarzi H., Miyashita C., Ito S., Sasaki S., Kitta T., Moriya K., Cho K., Morioka K., Kishi R., Shinohara N., Takeda M., Nonomura K.; Effects of adrenal androgens during the prenatal period on the second to fourth digit ratio in school-aged children. Steroids. 113 46-51, 2016.
  64. Minatoya M., Nakajima S., Sasaki S., Araki A., Miyashita C., Ikeno T., Nakajima T., Goto Y., Kishi R.; Effects of prenatal phthalate exposure on thyroid hormone levels, mental and psychomotor development of infants: The Hokkaido Study on Environment and Children’s Health. Sci Total Environ. 565 1037-43, 2016.
  65. Miyashita C., Sasaki S., Ikeno T., Arak A., Ito S., Kajiwara J., Todaka T., Hachiya N., Yasutake A., Murata K., Nakajima T. and Kishi R..; Effects of in utero exposure to polychlorinated biphenyls, methylmercury, and polyunsaturated fatty acids on birth size, Sci Total Environ 533, 256-265, 2015
  66. Mitsui T., Araki A., Imai A., Sato S., Miyashita C., Itoh S., Sasaki S., Kitta T., Moriya K., Cho K., Morioka K., Kishi R., Nonomura K.; Effects of prenatal Leydig cell function on the ratio of the second to fourth digit lengths in school-aged children. PLOS One. 10(3) :e0120636, 2015
  67. Jia X., Harada Y., Tagawa M., Naito H., Hayashi Y., Yetti H., Kato M., Sasaki S., Araki A., Miyashita C., Ikeno T., Kishi R., Nakajima T.; Prenatal maternal blood triglyceride and fatty acid levels in relation to exposure to di(2-ethylhexyl)phthalate: a cross-sectional study. Environ Health Prev Med. 20 (3):168-78, 2015.
  68. Jia X., Tagawa T., Yatsuya H., Naito H., Hayashi Y., Husna Y., Sasaki S., Araki A., Miyashita C., Ikeno T., Kishi R., Nakajima T.; Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study. J Perinat Med. 43 (5):565-75, 2015.
  69. M. A. Verner, A. E. Loccisano, N. H. Morken, M. Yoon, H. Wu, R. McDougall, M. Maisonet, M. Marcus, R. Kishi, C. Miyashita, M. H. Chen, W. S. Hsieh, M. E. Andersen, H. J. Clewell, 3rd and M. P. Longnecker.; Associations of Perfluoroalkyl Substances (PFASs) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK), Environ Health Perspect. ;123(12):1317-24, 2015
  70. Miyashita C., Sasaki S., Saijo Y., Okada E., Kobayashi S., Baba T., Kajiwara J., Todaka T., Iwasaki Y., Nakazawa H., Hachiya N., Yasutake A., Murata K. and Kishi R.. ; Demographic, behavioral, dietary, and socioeconomic characteristics related to persistent organic pollutants and mercury levels in pregnant women in Japan, Chemosphere.133, 13-21, 2015
  71. Kishi R., Nakajima T., Goudarzi H., Kobayashi S., Sasaki S., Okada E., Miyashita C., Ito S., Araki A., Ikeno T., Iwasaki Y. and Nakazawa H.,; The Association of Prenatal Exposure to Perfluorinated Chemicals with Maternal Essential and Long Chain Polyunsaturated Fatty Acids during Pregnancy and the Birth Weight of their Offspring: The Hokkaido Study, Environ Health Perspect. 124, (10):1038-45, 2015
  72. Otake Y., Nakajima S., Uno A., Kato S., Sasaki S., Yoshioka E., Ikeno T., Kishi R.; Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study. Environ Health Prev Med. 19 (1):30-45, 2014.
  73. Okada E., Sasaki S., Kashino I., Matsuura H., Miyashita C., Kobayashi S., Itoh K., Ikeno T., Tamakoshi A., Kishi R.; Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood. Environ Int. 65 127-134, 2014.
  74. Kawamoto T., Nitta H., Murata K., Toda E., Tsukamoto N., Hasegawa M., Yamagata Z., Kayama F., Kishi R., Ohya Y., Saito H., Sago H., Okuyama M., Ogata T., Yokoya S., Koresawa Y., Shibata Y., Nakayama S., Michikawa T., Takeuchi A., Satoh H., Working Group of the Epidemiological Research for Children’s Environmental Health; Rationale and study design of the Japan environment and children’s study (JECS). BMC Public Health. 14 25-32, 2014.
  75. Araki A., Mitsui T., Miyashita C., Nakajima T., Naito H., Ito S., Sasaki S., Cho K., Ikeno T., Nonomura K., Kishi R.; Association between maternal exposure to di(2-ethylhexyl) phthalate and reproductive hormone levels in fetal blood: The Hokkaido Study on Environment and Children’s Health. PLOS ONE. 9 (10):e109039, 2014.
  76. Yamada T., Morikawa M., Yamada T., Kishi R., Sengoku K., Endo T., Saito T., Cho K., Minakami H.; First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies. Arch Gynecol Obstet. 287 (1):9-14, 2013.
  77. Okada E., Kashino I., Matsuura H., Sasaki S., Miyashita C., Yamamoto J., Ikeno T., Ito M. Y., Matsumura T., Tamakoshi A., Kishi R.; Temporal trends of perfluoroalkyl acids in plasma samples of pregnant women in Hokkaido, Japan, 2003-2011. Environ Int. 60 89-96, 2013.
  78. Kobayashi S., Sata F., Sasaki S., Ban S., Miyashita C., Okada E., Limpar M., Yoshioka E., Kajiwara J., Todaka T., Saijo Y., Kishi R.; Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women. Toxicol Lett. 219 (3):269-278, 2013.
  79. Kishi R., Kobayashi S., Ikeno T., Araki A., Miyashita C., Itoh S., Sasaki S., Okada E., Kobayashi S., Kashino I., Itoh K., Nakajima S., Health. The members of the Hokkaido Study on Environment and Children’s; Ten Years of Progress in the Hokkaido Birth Cohort Study on Environment and Children’s Health: Cohort Profile – Updated 2013. Environ Health Prev Med. 18 (6):429-450, 2013.
  80. Yila TA, Sasaki S, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, Endo T, Sengoku K, Kishi R: Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and tobacco smoking on infant birth weight in a Japanese population. J Epidemiol 22:91-102, 2012
  81. Kanazawa A, Miyasita C, Okada E, Kobayashi S, Washino N, Sasaki S, Yoshioka E, Mizutani F, Chisaki Y, Saijo Y, Kishi R: Blood persistent organochlorine pesticides in pregnant women in relation to physical and environmental variables in The Hokkaido Study on Environment and Children’s Health. Sci Total Environ, 426:73-82, 2012
  82. Okada E, Sasaki S, Saijo Y, Washino N, Miyashita C, Kobayashi S, Konishi K, Ito YM, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R: Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants. Environ Res. 112:118-125. 2012
  83. Todaka T, Hirakawa H, Kajiwara J, Onozuka D, Sasaki S, Miyashita C, Yoshioka E, Yuasa M, Kishi R, Iida T, Uchi H, Furue M: Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, Japan. Chemosphere. 85:1694-1700, 2011
  84. Sasaki S, Braimoh TS, Yila TA, Yoshioka E, Kishi R: Self-reported tobacco smoke exposure and plasma cotinine levels during pregnancy – A validation study in Northern Japan. Sci Total Environ. 412-413:114-118, 2011
  85. Miyashita C, Sasaki S, Saijo Y, Washino N, Okada E, Kobayashi S, Konishi K, Kajiwara J, Todaka T, Kishi R: Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy. Environ Res. 111:551-558, 2011
  86. Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F, Saijo Y, Kurahashi N, Tamaki J, Endo T, Sengoku K, Nonomura K, Minakami H: Cohort Profile: The Hokkaido Study on Environment and Children’s Health in Japan. Int J Epidemiol. 40:611-618, 2011
  87. Todaka T, Hirakawa H, Kajiwara J, Hori T, Tobiishi K, Yasutake D, Onozuka D, Sasaki S, Miyashita C, Yoshioka E, Yuasa M, Kishi R, Iida T, Furue M: Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milk. Chemosphere. 78:185-192, 2010
  88. Sata F, Kurahashi N, Ban S, Moriya K, Tanaka KD, Ishizuka M, Nakao H, Yahata Y, Imai H, Kakizaki H, Nonomura K, Kishi R: Genetic polymorphisms of 17 beta-hydroxysteroid dehydrogenase 3 and the risk of hypospadias. J Sex Med. 7:2729-2738, 2010
  89. Washino N, Saijo Y, Sasaki S, Kato S, Ban S, Konishi K, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R: Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth. Environ Health Perspect. 117:660-667, 2009
  90. Konishi K, Sasaki S, Kato S, Ban S, Washino N, Kajiwara J, Todaka T, Hirakawa H, Hori T, Yasutake D, Kishi R: Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight. Environ Res. 109:906-913, 2009
  91. Sata F, Toya S, Yamada H, Suzuki K, Saijo Y, Yamazaki A, Minakami H, Kishi R: Proinflammatory cytokine polymorphisms and the risk of preterm birth and low birthweight in a Japanese population. Mol Hum Reprod. 15:121-130, 2009
  92. Baba T, Endo T, Sata F, Nagasawa K, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Moriwaka O, Kamiya H, Yamada H, Minakami H, Kishi R, Saito T: The contributions of resistin and adiponectin gene single nucleotide polymorphisms to the genetic risk for polycystic ovary syndrome in a Japanese population. Gynecol Endocrinol. 25:498-503, 2009
  93. Todaka T, Hori T, Hirakawa H, Kajiwara J, Yasutake K, Onozuka D, Washino N, Konishi K, Sasaki S, Yoshioka E, Yuasa M, Kishi R, Iida T, Furue M: Concentrations and congener profiles of non-dioxin-like polychlorinated biphenyls in blood collelcted from 195 pregnant women in Sapporo City, Japan. Organohalogen Compounds. 70:1597-1600, 2008
  94. Todaka T, Hori T, Hirakawa H, Kajiwara J, Yasutake D, Onozuka D, Kato S, Sasaki S, Nakajima S, Saijo Y, Sata F, Kishi R, Iida T, Furue M: Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan. Chemosphere. 73:923-931, 2008
  95. Todaka T, Hirakawa H, Kajiwara J, Hori T, Tobiishi K, Onozuka D, Kato S, Sasaki S, Nakajima S, Saijo Y, Sata F, Kishi R, Iida T, Furue M: Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan. Chemosphere. 72:1152-1158, 2008
  96. Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R: Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1. Am J Epidemiol. 167:719-726, 2008
  97. Kishi R, Sata F, Yoshioka E, Ban S, Sasaki S, Konishi K, Washino N: Exploiting gene-environment interaction to detect adverse health effects of environmental chemicals on the next generation. Basic Clin Pharmacol Toxicol. 102:191-203, 2008
  98. Kajiwara J, Todaka T, Hirakawa H, Hori T, Yasutake D, Onozuka D, Washino N, Konishi K, Sasaki S, Yoshioka E, Yuasa M, Kishi R, Iida T, Yoshimura T, Furue M: Concentrations of dioxin and related chemicals in blood and breast milk collected from 125 mothers in Hokkaido, Japan. Organohalogen Compounds. 70:1594-1596, 2008
  99. Ban S, Sata F, Kurahashi N, Kasai S, Moriya K, Kakizaki H, Nonomura K, Kishi R: Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias. Hum Reprod. 23:1466-1471, 2008
  100. Washino N, Saijo Y, Konishi K, Kato S, Sasaki S, Ban S, Kajiwara J, Todaka T, Hirakawa H, Hori T, Inoue S, Kishi R: The effect of prenatal exposure to dioxins on cord serum LgE. Organohalogen Compounds. 69:2106-2108, 2007
  101. Todaka T, Hirakawa H, Kajiwara J, Hori T, Tobiishi K, Onozuka D, Kato S, Sasaki S, Nakajima S, Saijo Y, Sata F, Kishi R, Iida T, Furue M: Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan. Chemosphere. 69:1228-1237, 2007
  102. Konishi K, Sasaki S, Kato S, Ban S, Washino N, Kajiwara J, Todaka T, Hirakawa H, Hori T, Inoue S, Kishi R: Effects of Prenatal Exposure to Dioxins and Methyl Mercury on Birth Weight. Organohalogen Compounds. 69:2109-2111, 2007
  103. Ban S, Kondo T, Sasaki S, Konishi K, Washino N, Kajiwara J, Todaka T, Hirakawa H, Ishizuka M, Fujita S, Kishi R: Correlations among serum PCB/dioxin levels, smoking status, and gene polymorphisms in mothers from Hokkaido, Japan. Organohalogen Compounds. 69:2039-2041, 2007
  104. Ban S, Kondo T, Ishizuka M, Sasaki S, Konishi K, Washino N, Fujita S, Kishi R: Using microarray analysis to evaluate genetic polymorphisms involved in the metabolism of environmental chemicals. Fukuoka Igaku Zasshi. 98:208-214, 2007
  105. Baba T, Endo T, Sata F, Honnma H, Kitajima Y, Hayashi T, Manase K, Kanaya M, Yamada H, Minakami H, Kishi R, Saito T: Polycystic ovary syndrome is associated with genetic polymorphism in the insulin signaling gene IRS-1 but not ENPP1 in a Japanese population. Life Sci. 81:850-854, 2007
  106. Sasaki S, Kondo T, Sata F, Saijo Y, Katoh S, Nakajima S, Ishizuka M, Fujita S, Kishi R: Maternal smoking during pregnancy and genetic polymorphisms in the Ah receptor, CYP1A1 and GSTM1 affect infant birth size in Japanese subjects. Mol Hum Reprod. 12:77-83, 2006
  107. Nakajima S, Saijo Y, Kato S, Sasaki S, Uno A, Kanagami N, Hirakawa H, Hori T, Tobiishi K, Todaka T, Nakamura Y, Yanagiya S, Sengoku Y, Iida T, Sata F et al: Effects of prenatal exposure to polychlorinated biphenyls and dioxins on mental and motor development in Japanese children at 6 months of age. Environ Health Perspect. 114:773-778, 2006
  108. Suzuki K, Sata F, Yamada H, Saijo Y, Tsuruga N, Minakami H, Kishi R: Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss. J Reprod Immunol. 70:99-108, 2006
  109. Shimada S, Nishida R, Takeda M, Iwabuchi K, Kishi R, Onoe K, Minakami H, Yamada H: Natural killer, natural killer T, helper and cytotoxic T cells in the decidua from sporadic miscarriage. Am J Reprod Immunol. 56:193-200, 2006
  110. Sata F, Yamada H, Suzuki K, Saijo Y, Yamada T, Minakami H, Kishi R: Functional maternal catechol-O-methyltransferase polymorphism and fetal growth restriction. Pharmacogenet Genomics. 16:775-781, 2006
  111. Kajiwara J, Todaka T, Hirakawa H, Hori T, Iida T, Washino N, Konishi K, Matsuzawa S, Ban S, Sata F, Kishi R, Yoshimura T: Dioxin and related chemicals concentration in human milk. Organohalogen Compounds. 68:1608-1610, 2006
  112. Kurahashi N, Sata F, Kasai S, Shibata T, Moriya K, Yamada H, Kakizaki H, Minakami H, Nonomura K, Kishi R: Maternal genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 and the risk of hypospadias. Mol Hum Reprod. 11:93-98, 2005
  113. Kurahashi N, Kasai S, Shibata T, Kakizaki H, Nonomura K, Sata F, Kishi R: Parental and neonatal risk factors for cryptorchidism. Med Sci Monit. 11:CR274-283, 2005
  114. Yamada H, Sata F, Saijo Y, Kishi R, Minakami H: Genetic factors in fetal growth restriction and miscarriage. Semin Thromb Hemost. 31:334-345, 2005
  115. Yamada H, Shimada S, Morikawa M, Iwabuchi K, Kishi R, Onoe K, Minakami H: Divergence of natural killer cell receptor and related molecule in the decidua from sporadic miscarriage with normal chromosome karyotype. Mol Hum Reprod. 11:451-457, 2005
  116. Kurahashi N, Murakumo M, Kakizaki H, Nonomura K, Koyanagi T, Kasai S, Sata F, Kishi R: The estimated prevalence of hypospadias in Hokkaido, Japan. J Epidemiol. 14:73-77, 2004
  117. Inoue K, Okada F, Ito R, Kato S, Sasaki S, Nakajima S, Uno A, Saijo Y, Sata F, Yoshimura Y, Kishi R, Nakazawa H: Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy. Environ Health Perspect. 112:1204-1207, 2004
  118. Yamada H, Shimada S, Kato EH, Morikawa M, Iwabuchi K, Kishi R, Onoe K, Minakami H: Decrease in a specific killer cell immunoglobulin-like receptor on peripheral natural killer cells in women with recurrent spontaneous abortion of unexplained etiology. Am J Reprod Immunol. 51:241-247, 2004
  119. Yamada H, Sata F, Kato EH, Saijo Y, Kataoka S, Morikawa M, Shimada S, Yamada T, Kishi R, Minakami H: A polymorphism in the CYP17 gene and intrauterine fetal growth restriction. Mol Hum Reprod. 10:49-53, 2004
  120. Yamada H, Morikawa M, Furuta I, Kato EH, Shimada S, Sata F, Kishi R, Minakami H: Circulating cytokines during early pregnancy in women with recurrent spontaneous abortion: decreased TNF-alpha levels in abortion with normal chromosome karyotype. Hokkaido Igaku Zasshi. 79:237-241, 2004
  121. Shimada S, Kato EH, Morikawa M, Iwabuchi K, Nishida R, Kishi R, Onoe K, Minakami H, Yamada H: No difference in natural killer or natural killer T-cell population, but aberrant T-helper cell population in the endometrium of women with repeated miscarriage. Hum Reprod. 19:1018-1024. 2004
  122. Saijo Y, Sata F, Yamada H, Suzuki K, Sasaki S, Kondo T, Gong YY, Kato EH, Shimada S, Morikawa M, Minakami H, Kishi R: Ah receptor, CYP1A1, CYP1A2 and CYP1B1 gene polymorphisms are not involved in the risk of recurrent pregnancy loss. Mol Hum Reprod. 10:729-733, 2004
  123. Saijo Y, Sata F, Yamada H, Konodo T, Kato EH, Kataoka S, Shimada S, Morikawa M, Minakami H, Kishi R: Interleukin-4 gene polymorphism is not involved in the risk of recurrent pregnancy loss. Am J Reprod Immunol. 52:143-146, 2004
  124. Saijo Y, Sata F, Yamada H, Kondo T, Kato EH, Kishi R: Single nucleotide polymorphisms in the promoter region of the interleukin-6 gene and the risk of recurrent pregnancy loss in Japanese women. Fertil Steril. 81:374-378, 2004
  125. Bai J, Sata N, Nagai H, Wada T, Yoshida K, Mano H, Sata F, Kishi R: Genistein-induced changes in gene expression in Panc 1 cells at physiological concentrations of genistein. Pancreas. 29:93-98, 2004
  126. Sata F, Yamada H, Yamada A, Kato EH, Kataoka S, Saijo Y, Kondo T, Tamaki J, Minakami H, Kishi R: A polymorphism in the CYP17 gene relates to the risk of recurrent pregnancy loss. Mol Hum Reprod. 9:725-728, 2003
  127. Sata F, Yamada H, Kondo T, Gong Y, Tozaki S, Kobashi G, Kato EH, Fujimoto S, Kishi R: Glutathione S-transferase M1 and T1 polymorphisms and the risk of recurrent pregnancy loss. Mol Hum Reprod. 9:165-169, 2003
  128. Yamada H, Furuta I, Kato EH, Kataoka S, Usuki Y, Kobashi G, Sata F, Kishi R, Fujimoto S: Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reprod Toxicol 2002, 16:735-739
  129. Yamada H, Furuta I, Kato EH, Kataoka S, Usuki Y, Kobashi G, Sata F, Kishi R, Fujimoto S: Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reprod Toxicol. 16:735-739, 2002
  130. Kobashi G, Yamada H, Asano T, Nagano S, Hata A, Kishi R, Fujimoto S, Kondo K: Absence of association between a common mutation in the methylenetetrahydrofolate reductase gene and preeclampsia in Japanese women. Am J Med Genet. 93:122-125, 2000
  131. Kobashi G, Yamada H, Asano T, Nagano S, Hata A, Kishi R, Kondo K, Fujimoto S: The factor V Leiden mutation is not a common cause of pregnancy-induced hypertension in Japan. Semin Thromb Hemost. 25:487-489, 1999

2. Indoor air quality and related athma/allergy including sick-building syndromes (25 papers)

  1. Bastiaensen M., Ait Bamai Y., Araki A., Van den Eede N., Kawai T., Tsuboi T., Kishi R., covaci A. Biomonitoring of organophosphate flame retardants and plasticizers in children: associations with house dust and housing characteristics in Japan. Environ Res, 172, 543-551, 2019
  2. Kishi R., Ketema R., Ait Bamai Y., Araki A., Kawai T., Tsuboi T., Saito I., Yoshioka E., Saito T.; Indoor Environmental Pollutants and Their Association with Sick House Syndrome among Adults and Children in Elementary School. Building and Environmnet. 136 293-301, 2018.
  3. Ait Bamai Y., Araki A., Kawai T., Tsuboi T., Saito I., Yoshioka E., Cong S., Kishi R.; Exposure to phthalates in house dust and associated allergies in children aged 6-12years. Environ Int. 96 16-23, 2016.
  4. Ait Bamai, Y .Araki, A. Kawai, T. Tsuboi, T. Yoshioka, E. Kanazawa, A. Cong, S. Kishi, R.; Comparisons of urinary phthalate metabolites and daily phthalate intakes among Japanese families. Int J Hyg Environ Health. 218[5]:461-70, 2015
  5. Ait Bamai Y., Shibata E., Saito I., Araki A., Kanazawa A., Morimoto K., Nakayama K., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R.; Exposure to house dust phthalates in relation to asthma and allergies in both children and adults. Sci Total Environ. 485-486 153-163, 2014.
  6. Ait Bamai Y., Araki A., Kawai T., Tsuboi T., Saito I., Yoshioka E., Kanazawa A., Tajima S., Cong S., Tamakoshi A., Kishi R.; Associations of phthalate concentrations in floor dust and multi-surface dust with the interior materials in Japanese dwellings. Sci Total Environ. 468-469 147-157, 2014.
  7. Cong S., Araki A., Ukawa S., Ait Bamai Y., Tajima S., Kanazawa A., Yuasa M., Tamakoshi A., Kishi R.; Association of Mechanical Ventilation and Flue Use in Heaters With Asthma Symptoms in Japanese Schoolchildren: A Cross-Sectional Study in Sapporo, Japan. J Epidemiol. 24 (3):230-238, 2014.
  8. Araki A., Saito I., Kanazawa A., Morimoto K., Nakayama K., Shibata E., Tanaka M., Takigawa T., Yoshimura T., Chikara H., Saijo Y., Kishi R.; Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants. Indoor Air. 24 (1):3-15, 2014
  9. Tajima S., Araki A., Kawai T., Tsuboi T., Ait Bamai Y., Yoshioka E., Kanazawa A., Cong S., Kishi R.; Detection and intake assessment of organophosphate flame retardants in house dust in Japanese dwellings. Sci Total Environ. 478 190-199, 2014.
  10. Ukawa S., Araki A., Kanazawa A., Yuasa M., Kishi R.; The relationship between atopic dermatitis and indoor environmental factors: a cross-sectional study among Japanese elementary school children. Int Arch Occup Environ Health. 86 (7):777-787, 2013.
  11. Takigawa T., Saijo Y., Morimoto K., Nakayama K., Shibata E., Tanaka M., Yoshimura T., Chikara H., Kishi R.; A longitudinal study of aldehydes and volatile organic compounds associated with subjective symptoms related to sick building syndrome in new dwellings in Japan. Sci Total Environ. 417-418 61-67, 2012
  12. Araki A., Watanabe K., Eitaki Y., Kawai T., Kishi R.; The feasibility of aromatherapy massage to reduce symptoms of Idiopathic Environmental Intolerance: a pilot study. Complement Ther Med. 20 (6):400-408, 2012.
  13. Araki A, Tsuboi T, Kawai T, Ait Bamai Y, Takeda T, Yoshioka E, Kishi R: Validation of diffusive mini-samplers for aldehyde and VOC and its feasibility for measuring the exposure levels of elementary school children. J Environ Monit. 14:368-374, 2012
  14. Araki A, Kanazawa A, Kawai T, Eitaki Y, Morimoto K, Nakayama K, Shibata E, Tanaka M, Takigawa T, Yoshimura T, Chikara H, Saijo Y, Kishi R: The relationship between exposure to microbial volatile organic compound and allergy prevalence in single-family homes. Sci Total Environ. 423:18-26, 2012
  15. Saijo Y, Kanazawa A, Araki A, Morimoto K, Nakayama K, Takigawa T, Tanaka M, Shibata E, Yoshimura T, Chikara H, Kishi R: Relationships between mite allergen levels, mold concentrations, and sick building syndrome symptoms in newly built dwellings in Japan. Indoor Air. 21:253-263, 2011
  16. Araki A, Kawai T, Eitaki Y, Kanazawa A, Morimoto K, Nakayama K, Shibata E, Tanaka M, Takigawa T, Yoshimura T, Chikara H, Saijo Y, Kishi R; Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes. Sci Total Environ. 408 (10):2208-2215, 2010.
  17. Kanazawa A, Saito I, Araki A, Takeda M, Ma M, Saijo Y, Kishi R: Association between indoor exposure to semi-volatile organic compounds and building-related symptoms among the occupants of residential dwellings. Indoor Air. 20:72-84, 2010
  18. Takigawa T., Wang B. L., Saijo Y., Morimoto K., Nakayama K., Tanaka M., Shibata E., Yoshimura T., Chikara H., Ogino K., Kishi R.; Relationship between indoor chemical concentrations and subjective symptoms associated with sick building syndrome in newly built houses in Japan. Int Arch Occup Environ Health. 83 (2):225-235, 2010
  19. Takigawa T, Wang BL, Sakano N, Wang DH, Ogino K, Kishi R: A longitudinal study of environmental risk factors for subjective symptoms associated with sick building syndrome in new dwellings. Sci Total Environ. 407:5223-5228, 2009
  20. Takeda M, Saijo Y, Yuasa M, Kanazawa A, Araki A, Kishi R: Relationship between sick building syndrome and indoor environmental factors in newly built Japanese dwellings. Int Arch Occup Environ Health. 82:583-593, 2009
  21. Kishi R, Saijo Y, Kanazawa A, Tanaka M, Yoshimura T, Chikara H, Takigawa T, Morimoto K, Nakayama K, Shibata E: Regional differences in residential environments and the association of dwellings and residential factors with the sick house syndrome: a nationwide cross-sectional questionnaire study in Japan. Indoor Air. 19:243-254, 2009
  22. Araki A, Eitaki Y, Kawai T, Kanazawa A, Takeda M, Kishi R: Diffusive sampling and measurement of microbial volatile organic compounds in indoor air. Indoor Air. 19:421-432, 2009
  23. Eitaki Y, Kawai T, Kishi R, Sakurai H, Ikeda M: Stability in urine of authentic phenylglyoxylic and mandelic acids as urinary markers of occupational exposure to styrene. J Occup Health. 50:221-228, 2008
  24. Saijo Y, Sata F, Mizuno S, Yamaguchi K, Sunagawa H, Kishi R; Indoor Airborne Mold Spores in Newly Built Dwellings. Environ Health Prev Med. 10 (3):157-161, 2005.
  25. Saijo Y, Kishi R, Sata F, Katakura Y, Urashima Y, Hatakeyama A, Kobayashi S, Jin K, Kurahashi N, Kondo T, Gong YY, Umemura T: Symptoms in relation to chemicals and dampness in newly built dwellings. Int Arch Occup Environ Health. 77:461-470, 2004

3. Experimental studies on environmental toxicology (34 papers)

  1. Matsumoto Y, Ide F, Kishi R, Akutagawa T, Sakai S, Nakamura M, Ishikawa T, Fujii-Kuriyama Y, Nakatsuru Y: Aryl hydrocarbon receptor plays a significant role in mediating airborne particulate-induced carcinogenesis in mice. Environ Sci Technol 2007, 41:3775-3780.
  2. Ma M, Kondo T, Ban S, Umemura T, Kurahashi N, Takeda M, Kishi R: Exposure of prepubertal female rats to inhaled di(2-ethylhexyl)phthalate affects the onset of puberty and postpubertal reproductive functions. Toxicol Sci. 93:164-171, 2006
  3. Umemura T, Kurahashi N, Kondo T, Katakura Y, Sata F, Kawai T, Kishi R: Acute effects of styrene inhalation on the neuroendocrinological system of rats and the different effects in male and female rats. Arch Toxicol. 79:653-659, 2005
  4. Kurahashi N, Kondo T, Omura M, Umemura T, Ma M, Kishi R: The effects of subacute inhalation of di (2-ethylhexyl) phthalate (DEHP) on the testes of prepubertal Wistar rats. J Occup Health. 47:437-444, 2005
  5. Kishi R, Sata F, Katakura Y, Wang RS, Nakajima T: Effects of pregnancy, age and sex in the metabolism of styrene in rat liver in relation to the regulation of cytochrome P450 enzymes. J Occup Health. 47:49-55, 2005
  6. Katakura Y, Kishi R, Ikeda T, Miyake H: Effects of prenatal styrene exposure on postnatal development and brain serotonin and catecholamine levels in rats. Environ Res. 85:41-47, 2001
  7. Katakura Y, Kishi R, Ikeda T, Miyake H: Effects of prenatal exposure to styrene on neurochemical levels in rat brain. Toxicology Lett. 105:239-249, 1999
  8. Kishi R, Chen BQ, Katakura Y, Ikeda T, Miyake H: Effect of prenatal exposure to styrene on the neurobehavioral development, activity, motor coordination, and learning behavior of rats. Neurotoxicol Teratol. 17:121-130, 1995
  9. Kishi R, Harabuchi I, Ikeda T, Katakura Y, Miyake H: Acute effects of trichloroethylene on blood concentrations and performance decrements in rats and their relevance to humans. Brit J Ind Med. 50:470-480, 1993
  10. Ikeda T, Katakura Y, Kishi R, Miyake H: Acute neurobehavioral effects of co-inhalation of toluene and n-hexane on schedule-controlled behavior in rats. Environ Res. 63:70-81, 1993
  11. Harabuchi I, Kishi R, Ikeda T, Kiyosawa H, Miyake H: Circadian variations of acute toxicity and blood and brain concentrations of inhaled toluene in rats. Br J Ind Med. 50:280-286, 1993
  12. Katakura Y, Kishi R, Okui T, Ikeda T, Miyake H: Distribution of radioactivity from 14C- formaldehyde in pregnant mice and their fetuses. Brit J Ind Med. 50:176-182, 1993
  13. Nakajima T, Wang RS, Katakura Y, Kishi R, Elovaara E, Park SS, Gelboin HV, Vainio H: Sex-, age- and pregnancy-induced changes in the metabolism of Toluene and Trichloroethylene in Rat-Liver in Relation to the Regulation of cytochrome P450IIE1 and cytochrome P450IIC11 content. J Pharmacol Exp Ther. 261:869-874, 1992
  14. Kishi R, Katakura Y, Okui T, Chen BQ, Nasu T, Wang RS, Ogawa H, Ikeda T, Miyake H: Distribution and effects of styrene on fetus in pregnancy. Jpn J Tox Env Health. 38:P2-P2, 1992
  15. Mimura M, Namiki A, Kishi R, Ikeda T, Miyake H, Iwasaki H: Central Cholinergic Action Produces Antagonism to Ketamine Anesthesia. Acta Anaesth Scand. 36:460-462, 1992
  16. Kishi R, Katakura Y, Ikeda T, Chen BQ, Miyake H: Neurochemical effects in rats following gestational exposure to styrene. Toxicol Lett. 63:141-146, 1992
  17. Mimura M, Namiki A, Kishi R, Ikeda T, Miyake H: Antagonistic effect of physostigmine on ketamine-induced anesthesia. Psychopharmacology (Berl). 102:399-403, 1990
  18. Yamamura K, Terayama K, Yamamoto N, Kohyama A, Kishi R: Effects of acute lead acetate exposure on adult guinea pigs: electrophysiological study of the inner ear. Fundam Appl Toxicol. 13:509-515, 1989
  19. Kishi R, Katakura Y, Okui T, Ogawa H, Ikeda T, Miyake H: Placental transfer and tissue distribution of 14C styrene: an autoradiographic study in mice. Brit J Ind Med. 46:376-383, 1989
  20. Kishi R, Harabuchi I, Ikeda T, Yokota H, Miyake H: Neurobehavioural effects and pharmacokinetics of toluene in rats and their relevance to man. Br J Ind Med. 45:396-408, 1988
  21. Yamamura K, Maehara N, Terayama K, Ueno N, Kohyama A, Sawada Y, Kishi R: Effects of lead acetate on guinea pig–cochlear microphonics, action potential, and motor nerve conduction velocity. Bull Environ Contam Toxicol. 38:571-579, 1987
  22. Yamamura K, Maehara N, Ohno H, Ueno N, Kohyama A, Satoh T, Shimoda A, Kishi R: Effects of methylmercuric chloride of low concentration on the rat nervous system. Bull Environ Contam Toxicol. 38:985-993, 1987
  23. Yamamura K, Maehara N, Ueno N, Ohno H, Kishi R: The effects of methylmercury chloride of low concentration on the rat brain. Ind Health. 24:235-241, 1986
  24. Yamamura K, Kishi R, Maehara N, Sadamoto T, Uchino E: An experimental study of the effects of lead acetate on hearing. Cochlear microphonics and action potential of the guinea pig. Toxicol Lett. 21:41-47, 1984
  25. Maehara N, Kishi R, Sadamoto T, Harabuchi I, Yamamura K, G.: Effects of 8 hour exposure to 40 Hz and 80 Hz low frequency sound at intensities below 100 dB (SPL) on the Rota-Rod Treadmill performance of guinea pigs. J Low Freq Noise & Vibr. 3:174-179, 1984
  26. Yamamura K, Kishi R, Sadamoto T, Kiyosawa H, Miyake H, Takekawa T, Sukegawa H, Iwadate Y: An investigation of the Medical Data Index (MDI) health questionnaire given to women VDT workers involved in advanced office automation–924 women clerks in a city bank with head and branch offices. Ind Health. 21:199-207, 1983
  27. Miyake H, Ikeda T, Maehara N, Harabuchi I, Kishi R, Yokota H: Slow learning in rats due to long-term inhalation of toluene. Neurobehav Toxicol Teratol. 5:541-548, 1983
  28. Kishi R, Ikeda T, Miyake H, Uchino E, Tsuzuki T, Inoue K: Effects of low lead exposure on neuro-behavioral function in the rat. Arch Environ Health. 38:25-33, 1983
  29. Maehara N, Kishi R, Sadamoto T, Harabuchi I, Yamamura K: Effect of infrasound and low frequency sound exposure at intensities below 100dB(SPL) on the Rota-Rod treadmill performance of Guinea pigs. J Low Freq Noise & Vibr . 2:37-41, 1983
  30. Kishi R, Ikeda T, Miyake H, Uchino E, Tsuzuki T, Inoue K: Regional distribution of lead, zinc, iron and copper in suckling and adult rat brains. Brain Res. 251:180-182, 1982
  31. Yamamura K, Kishi R: Effects of infrasound on the rota-rod treadmill performance of rats. Eur J Appl Physiol Occup Physiol. 45:81-86, 1980
  32. Ikeda T, Kishi R, Yamamura K, Miyake H, Sato M, Ishizu S: Behavioural effects in rats following repeated exposure to methyl bromide. Toxicol Lett. 6:293-299, 1980
  33. Ikeda T, Kishi R, Miyake H: Effects of long term exposure to trichloroethylene on learning
    behaviour in rats. Dev Toxicol Environ Sci. 8:91-94, 1980
  34. Kishi R, Hashimoto K, Shimizu S, and Kobayashi M. Behavioral Changes and mercury
    concentrations in tissues of rats exposed to mercury vapor.Toxcol. Applied Pharmacol. 46;555-566, 1978

4. Occupational Cancer Epidemiology and Neurobehavioral Disorders Among Workers Exposed to Environmental Chemicals (18 papers)

  1. Sato T, Kishi R, Gong Y, Katakura Y, Kawai T: Effects of styrene exposure on vibration perception threshold. Neurotoxicology. 30:97-102, 2009
  2. McLean D, Pearce N, Langseth H, Jappinen P, Szadkowska-Stanczyk I, Persson B, Wild P, Kishi R, Lynge E, Henneberger P, Sala M, Teschke K, Kauppinen T, Colin D, Kogevinas M et al: Cancer mortality in workers exposed to organochlorine compounds in the pulp and paper industry: an international collaborative study. Environ Health Perspect. 114:1007-1012, 2006
  3. Ma M, Umemura T, Mori Y, Gong Y, Saijoa Y, Sata F, Kawai T, Kishi R: Influence of genetic polymorphisms of styrene-metabolizing enzymes and smoking habits on levels of urinary metabolites after occupational exposure to styrene. Toxicol Lett. 160:84-91, 2005
  4. Gong YY, Kishi R, Kasai S, Katakura Y, Fujiwara K, Umemura T, Kondo T, Sato T, Sata F, Tsukishima E, Tozaki S, Kawai T: Visual Dysfunction in Workers Exposed to a Mixture of Organic Solvents. Neurotoxicology. 24:703-710, 2003
  5. Gong YY, Kishi R, Katakura Y, Tsukishima E, Fujiwara K, Kasai S, Sato T, Sata F, Kawai T: Relation between colour vision loss and occupational styrene exposure level. Occu Environ Med. 59:824-829, 2002
  6. Lee WJ, Teschke K, Kauppinen T, Andersen A, Jappinen P, Szadkowska-Stanczyk I, Pearce N, Persson B, Bergeret A, Facchini LA, Kishi R, Kielkowski D, Rix BA, Henneberger P, Sunyer J et al: Mortality from lung cancer in workers exposed to sulfur dioxide in the pulp and paper industry. Environ Health Perspect. 110:991-995, 2002
  7. Carel R, Boffetta P, Kauppinen T, Teschke K, Andersen A, Jappinen P, Pearce N, Rix BA, Bergeret A, Coggon D, Persson B, Szadkowska-Stanczyk I, Kielkowski D, Henneberger P, Kishi R et al: Exposure to asbestos and lung and pleural cancer mortality among pulp and paper industry workers. J Occup Environ Med. 44:579-584, 2002.
  8. Kishi R, Eguchi T, Yuasa J, Katakura Y, Arata Y, Harabuchi I, Kawai T, Masuchi A: Effects of low-level occupational exposure to styrene on color vision: dose relation with a urinary metabolite. Environ Res. 85:25-30, 2001
  9. Kishi R, Tozaki S, Gong YY: Impairment of Neurobehavioral Function and Color Vision Loss among Workers Exposed to Low Concentration of Styrene-A Review of Literatures. Ind Health. 38:120-126, 1999
  10. Yuasa J, Kishi R, Eguchi T, Harabuchi I, Kawai T, Ikeda M, Sugimoto R, Matsumoto H, Miyake H: Investigation on neurotoxicity of occupational exposure to cyclohexane: a neurophysiological study. Occu Environ Med. 53:174-176, 1996
  11. Yuasa J, Kishi R, Eguchi T, Harabuchi I, Arata Y, katakura Y, Imai T, Matsumoto H, Yokoyama H, Miyake H: A study of urinary mandelic acid. concentration and peripheral nerve conduction among styrene workers. Amer J Ind Med. 30:41-47, 1996
  12. Eguchi T, Kishi R, Harabuchi I, Yuasa J, Arata Y, Katakura Y , Miyake T.Impaired colour discrimination among workers exposed to styrene: relevance of urinary metabolite. Occu Environ Med. 534-538, 1995
  13. Kishi R, Doi R, Fukuchi Y, Satoh H, Satoh T, Ono A, Moriwaka F, Tashiro K, Takahata N, Sasatani H, Shirakashi H, Kamada T, Nakagawa K: Residual neurobehavioural effects associated with chronic exposure to mercury vapour. Occu Environ Med. 51:35-41, 1994
  14. Yasugi T, Kawai T, Mizunuma K, Kishi R, Harabuchi I, Yuasa J, Eguchi T, Sugimoto R, Seiji K, Ikeda T: Exposure monitoring and health effect studies of workers occupationally exposed to cyclohexane vapor. Int Arch Occup Environ Health. 65:343-350, 1994
  15. Kishi R, Doi R, Fukuchi Y, Satoh H, Satoh T, Ono A, Moriwaka F, Ashiro K, Takahata N: Subjective symptoms and neurobehavioral performances of ex-mercury miners at an average of 18 years after the cessation of chronic exposure to mercury vapor. Environ Res 62. 289-302. 1993
  16. Kishi R, Harabuchi I, Katakura Y,I keda T, Miyake H: Neurobehavioral effects of chronic occupational exposure to organic solvents among Japanese industrial painters. Environ Res. 62:303-313., 1993
  17. Kishi R, Itoh I, Ishizu S, Harabuchi I, Miyake H: Symptoms among workers with long-term exposure to methyl bromide —- An epidemiological study. Jpn J Ind Health. 3:241-250, 1991
  18. Kishi R, Tarumi T, Uchino E, Miyake H: Chromium content of organs of chromate workers with lung cancer. Am J Ind Med. 11:67-74. 1987

5. Occupational stress and physical and mental health of workers (32 papers)

  1. Bannai A., Yoshioka E., Saijo Y., Sasaki S., Kishi R and Tamakoshi A,; The risk of developing diabetes in association with long working hours differs by shift work schedules, Journal of Epidemiology 26(9):481-487, 2016
  2. Yoshioka E., Saijo Y., Kita T., Satoh H., Kawaharada M., Kishi R.; Effect of the interaction between employment level and psychosocial work environment on insomnia in male Japanese public service workers. Int J Behav Med. 20 (3):355-364, 2013.
  3. Sasaki S., Yoshioka E., Saijo Y., Kita T., Okada E., Tamakoshi A., Kishi R.; Relation between alcohol consumption and arterial stiffness: A cross-sectional study of middle-aged Japanese women and men. Alcohol. 47 (8):643-649, 2013.
  4. Kawaharada M., Ueda I., Yoshioka E., Hirano M., Ikeno T., Shindou Y., Kishi R.; Depression prevention program for workers of private companies: A randomized controlled trial. Open Journal of Nursing. 03 (01):114-121, 2013.
  5. Kita T, Yoshioka E, Satoh H, Saijo Y, Kawaharada M, Okada E, Kishi R: Short sleep duration and pPoor Sleep quality increase the risk of diabetes in Japanese workers with no family history of diabetes. Diabetes Care. 35:313-318, 2012
  6. Yoshioka E, Saijo Y, Kita T, Satoh H, Kawaharada M, Fukui T, Kishi R: Gender differences in insomnia and the role of paid work and family responsibilities. Soc Psychiatry Psychiatr Epidemiol. 47:651-663, 2012
  7. Yoshioka E, Saijo Y, Kita T, Okada E, Satoh H, Kawaharada M, Kishi R: Relation between self-reported sleep duration and arterial stiffness: a cross-sectional study of middle-age Japanese civil servants. Sleep. 34:1681-1686, 2011.
  8. Utsugi M, Saijo Y, Yoshioka E, Sato T, Horikawa N, Gong Y, Kishi R: Relationship between two alternative occupational stress models and arterial stiffness: a cross-sectional study among Japanese workers. Int Arch Occup Environ Health. 82:175-183, 2009
  9. Kawaharada M, Yoshioka E, Saijo Y, Fukui T, Ueno T, Kishi R: The effects of a stress inoculation training program for civil servants in Japan: a pilot study of a non-randomized controlled trial. Ind Health. 47:173-182, 2009
  10. Satoh H, Tomita K, Fujii S, Kishi R, Tsutsui H: Lower high-density lipoprotein cholesterol is a significant and independent risk for coronary artery disease in Japanese men. J Atheroscler Thromb. 16:792-798, 2009
  11. Satoh H, Kishi R, Tsutsui H: Metabolic syndrome is a significant and independent risk factor for increased arterial stiffness in Japanese subjects. Hypertens Res. 32:1067-1071, 2009
  12. Saijo Y, Utsugi M, Yoshioka E, Fukui T, Sata F, Nakagawa N, Hasebe N, Yoshida T, Kishi R: Inflammation as a cardiovascular risk factor and pulse wave velocity as a marker of early-stage atherosclerosis in the Japanese population. Environ Health Prev Med. 14:159-164, 2009
  13. Kishimoto N, Okita K, Takada S, Sakuma I, Saijo Y, Chiba H, Ishii K, Kishi R, Tsutsui H: Lipoprotein metabolism, insulin resistance, and adipocytokine levels in Japanese female adolescents with a normal body mass index and high body fat mass. Circ J. 73:534-539, 2009
  14. Yoshioka E, Saijo Y, Fukui T, Kawaharada M, Kishi R: Association between duration of daily visual display terminal work and insomnia among local government clerks in Japan. Am J Ind Med. 51:148-156, 2008
  15. Saijo Y, Yoshioka E, Fukui T, Kawaharada M, Kishi R: Relationship of socioeconomic status to C-reactive protein and arterial stiffness in urban Japanese civil servants. Soc Sci Med. 67:971-981, 2008
  16. Saijo Y, Utsugi M, Yoshioka E, Horikawa N, Sato T, Gong Y, Kishi R: The relationship of gamma-glutamyltransferase to C-reactive protein and arterial stiffness. Nutr Metab Cardiovasc Dis. 18:211-219, 2008
  17. Saijo Y, Yoshioka E, Fukui T, Kawaharada M, Sata F, Sato H, Kishi R: Effects of the interaction between interleukin-6 -634C/G polymorphism and smoking on serum C-reactive protein concentrations. Hypertens Res. 30:593-599, 2007
  18. Saijo Y, Yoshioka E, Fukui T, Kawaharada M, Sata F, Sato H, Kishi R: H pylori seropositivity and cytokine gene polymorphisms. World J Gastroenterol. 13:4445-4451, 2007
  19. Kawaharada M, Saijo Y, Yoshioka E, Sato T, Sato H, Kishi R: Relations of occupational stress to occupational class in Japanese civil servants–analysis by two occupational stress models. Ind Health. 45:247-255, 2007
  20. Satoh H, Nishino T, Tomita K, Saijo Y, Kishi R, Tsutsui H: Risk factors and the incidence of coronary artery disease in young middle-aged Japanese men: results from a 10-year cohort study. Intern Med. 45:235-239, 2006
  21. Saijo Y, Yoshioka E, Fukui T, Kawaharada M, Kishi R: Metabolic syndrome, C-reactive protein and increased arterial stiffness in Japanese subjects. Hypertens Res. 29:589-596, 2006
  22. Oyama N, Sakuma I, Kishimoto N, Saijo Y, Sakai H, Urasawa K, Kitabatake A, Kishi R, Tsutsui H: Low HDL-cholesterol, hypertension and impaired glucose tolerance as predictors of acute myocardial infarction in northern area of Japan. Hokkaido Igaku Zasshi. 81:25-30, 2006
  23. Utsugi M, Saijo Y, Yoshioka E, Horikawa N, Sato T, Gong Y, Kishi R: Relationships of occupational stress to insomnia and short sleep in Japanese workers. Sleep. 28:728-735, 2005
  24. Saijo Y, Utsugi M, Yoshioka E, Horikawa N, Sato T, Gong YY, Kishi R: Relationships of C-reactive protein, uric acid, and glomerular filtration rate to arterial stiffness in Japanese subjects. J Hum Hypertens. 19:907-913, 2005
  25. Saijo Y, Utsugi M, Yoshioka E, Horikawa N, Sato T, Gong Y, Kishi R: Relationship of beta2-microglobulin to arterial stiffness in Japanese subjects. Hypertens Res. 28:505-511, 2005
  26. Saijo Y, Utsugi M, Yoshioka E, Horikawa N, Sato T, Gong Y, Kishi R: Relationship of Helicobacter pylori infection to arterial stiffness in Japanese subjects. Hypertens Res. 28:283-292, 2005
  27. Saijo Y, Kiyota N, Kawasaki Y, Miyazaki Y, Kashimura J, Fukuda M, Kishi R: Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes Obes Metab. 6:249-258, 2004
  28. Fujiwara K, Tsukishima E, Kasai S, Masuchi A, Tsutsumi A, Kawakami N, Miyake H, Kishi R: Urinary catecholamines and salivary cortisol on workdays and days off in relation to job strain among female health care providers. Scand J Work Environ Health. 30:129-138, 2004
  29. Fujiwara K, Tsukishima E, Tsutsumi A, Kawakami N, Kishi R: Interpersonal conflict, social support, and burnout among home care workers in Japan. J Occup Health. 45:313-320, 2003
  30. Kishi R, Kitahara T, Masuchi A, Kasai S: Work-related reproductive, musculoskeletal and mental disorders among working women–history, current issues and future research directions. Ind Health. 40:101-112, 2002
  31. Kishi R, Kitahara T, Masuchi A, Kasai S: Work-related reproductive, musculoskeletal and mental disorders among working women–history, current issues and future research directions. Ind Health. 40:101-112, 2002
  32. Kishi R: Present status, health conditions, and work-related stress of women sorkers. Including future issues. Journal of Tokyo Medical University. 58:338-344, 2000

6. Social support networks and preventive care for the elderly (6 papers)

  1. Yoshioka E., Yamamoto S., Yasuda M., Saijo Y., Kishi R.; Spouse caregivers and behavioral and psychological symptoms of dementia. Aging Ment Health. 17 (8):966-972, 2013.
  2. Ukawa S, Yuasa M, Ikeno T, Yoshioka E, Satoh H, Murata W, Ikoma K, Kishi R: Randomised controlled pilot study in Japan comparing a home visit program using a Functioning Improvement Tool with a home visit with conversation alone. Australian J Ageing 2012 (Article first published online: 16 FEB 2012)
  3. Ukawa S, Yuasa M, Ikeno T, Ikoma K, Kishi R: The effect of a Functioning Improvement Tool home visit program on instrumental activities of daily living and depressive status in older people. Int J Geriatr Psychiatry 2011.
  4. Ukawa S, Satoh H, Yuasa M, Ikeno T, Kawabata T, Araki A, Yoshioka E, Murata W, Ikoma K, Kishi R: A randomized controlled trial of a Functioning Improvement Tool home-visit program and its effect on cognitive function in older persons. Int J Geriatr Psychiatry 2012, 27:557-64.
  5. Sato T, Kishi R, Suzukawa A, Horikawa N, Saijo Y, Yoshioka E: Effects of social relationships on mortality of the elderly: how do the influences change with the passage of time? Arch Gerontol Geriatr 2008, 47:327-339.
  6. Tsukishima E, Saito H, Shido K, Kobashi G, Ying-Yan G, Kishi R, Takeuchi S, Niino M, Kondo K, Sugimura I: Cranial computed tomography associated with development of functional dependence in a community-based elderly population. J Epidemiol 2002, 12:153-159.

7. Others (6 papers)

  1. Hanley S.J., Yoshioka E., Ito Y. and Kishi R.; HPV vaccination crisis in Japan. Lancet. 385 2571, 2015.
  2. Hanley S. J., Yoshioka E., Ito Y., Konno R., Sasaki Y., Kishi R., Sakuragi N.; An exploratory study of Japanese fathers’ knowledge of and attitudes towards HPV and HPV vaccination: does marital status matter? Asian Pac J Cancer Prev. 15 (4):1837-1843, 2014.
  3. Hanley S. J., Yoshioka E., Ito Y., Konno R., Hayashi Y., Kishi R., Sakuragi N.; Acceptance of and attitudes towards human papillomavirus vaccination in Japanese mothers of adolescent girls. Vaccine. 30 (39):5740-5747, 2012.
  4. Hanaoka T, Mita K, Hiramoto A, Suzuki Y, Maruyama S, Nakadate T, Kishi R, Okada K, Egusa Y: Survival prognosis of Japanese with severe motor and intellectual disabilities living in public and private institutions between 1961 and 2003. J Epidemiol 2010, 20:77-81.
  5. Handa Y, Fujita H, Honma S, Minakami H, Kishi R: Estrogen concentrations in beef and human hormone-dependent cancers. Ann Oncol 2009, 20:1610-1611.
  6. Yamamoto N, Kishi R, Katakura Y, Miyake H: Risk factors for human alveolar echinococcosis: a case-control study in Hokkaido, Japan. Ann Trop Med Parasitol. 95:689-696, 2001

Saff List